Differential roles of RIG-Ⅰ like receptors in SARS-CoV-2 infection

作     者：Duo-Meng Yang Ting-Ting Geng Andrew G.Harrison Peng-Hua Wang Duo?Meng Yang;Ting?Ting Geng;Andrew G.Harrison;Peng?Hua Wang

作者机构：Department of ImmunologySchool of MedicineUniversity of Connecticut Health CenterFarmingtonCT 06030USA 

出 版 物：《Military Medical Research》 (军事医学研究（英文版）)

年 卷 期：2022年第9卷第2期

页      面：262-264页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by a National Institutes of Health grant (No. R01AI132526) a UConn Health Startup fund to Wang P 

主　　题：Severe acute respiratory syndrome coronavirus 2 Pathogen pattern recognition receptor Melanoma differentiation-associated protein 5 Retinoic acid-inducible geneⅠ 

摘      要：Retinoic acid-inducible gene Ⅰ (RIG-Ⅰ) and melanoma differentiation-associated protein 5 (MDA5) sense viral RNA and activate antiviral immune *** we investigate their functions in human epithelial cells,the primary and initial target of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).A deficiency in MDA5,RIG-Ⅰ or mitochondrial antiviral signaling protein (MAVS) enhanced viral *** expression of the type I/III interferon(IFN) during infection was impaired in MDA5;and MAVS;,but not in RIG-Ⅰ;,when compared to wild type (WT) *** mRNA level of full-length angiotensin-converting enzyme 2 (ACE2),the cellular entry receptor for SARS-CoV-2,was approximately 2.5-fold higher in RIG-Ⅰ;than WT *** data demonstrate MDA5 as the predominant SARS-CoV-2 sensor,IFN-independent induction of ACE2 and anti-SARS-CoV-2 role of RIG-Ⅰ in epithelial cells.