Hyphenated LC-ABTS$t and LC-DAD-HRMS for simultaneous analysis and identification of antioxidant compounds in Astragalus emarginatus ***
作者机构：Analytical Chemistry of Bioactive Molecules and Pharmacognosy Team(CAMBAP)Hubert Curien Multidisciplinary Institute(IPHC)National Center for Scientific Research(CNRS)Faculty of PharmacyUniversity of StrasbourgIllkirch67400France Research Platform of Analysis and Environmental Science(PRASE)Lebanese UniversityHadath005Lebanon Faculty of AgronomyLebanese UniversityDekwaneh005Lebanon
出 版 物：《Journal of Pharmaceutical Analysis》 (药物分析学报（英文版）)
年 卷 期：2022年第12卷第2期
页 面：253-262页
核心收录：
学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学]
主 题：Antioxidant Astragalus emarginatus Catechol Flavonoids Hydroxycinnamates Caffeic acid Quercetin
摘 要：The compounds in leaf and stem extracts of Astragalus emarginatus Labill.(AEL),a plant species used in traditional Lebanese medicine,were investigated for antioxidant ***,the activity of various extracts was assessed using the Trolox equivalent antioxidant capacity,oxygen radical absorption capacity,and 2,2-diphenyl-1-picryl-hydrazyl-hydrate *** extract obtained using 30%ethanol showed the greatest *** antioxidant compounds in this extract were screened using a hyphenated high-performance liquid chromatography-2,2-azinobis-(3-ethylbenzothiazoline-6-sulfonate)radical(ABTS$t)system before being separated by ultra-high-performance liquid chromatography and identified using high-resolution mass spectrometry and ultra-violet-visible diode array *** 40 compounds were ***(caffeic,ferulic,and p-coumaric acid derivatives)and flavonoids(quercetin,luteolin,apigenin,and isorhamnetin derivatives)were the two main categories of the identified *** active compounds were identified as caffeic acid derivatives and quercetin *** addition,the catechol moiety was shown to be key to antioxidant *** study showed that AEL is a source of natural antioxidants,which may explain its medicinal use.
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