Mitochondrial Complex I deficiency: guilty in Parkinson’s disease

作     者：Melissa Vos 

作者机构：Institute of NeurogeneticsUniversity of LuebeckUKSHRatzeburger Allee 16023562LuebeckGermany 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2022年第7卷第5期

页      面：1371-1372页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：Projekt DEAL 

主　　题：impaired function. Complex 

摘      要：Mitochondrial Complex I(MCI)deficiency has been abundantly observed in Parkinson’s disease(PD);however,it remained elusive if this was a consequence of the disease defects or rather *** work in Nature by Gonzalez-Rodriguez and colleagues discovered MCI dysfunction to be sufficient to cause progressive parkinsonism.1 PD is characterized by the loss of dopaminergic neurons in the substantia nigra that is responsible for impaired motor function.