Regulatory RNAs,microRNA,long-non coding RNA and circular RNA roles in colorectal cancer stem cells

作     者：Hsiao-Mei Chao Teh-Wei Wang Edward Chern Shan-hui Hsu 

作者机构：Department of PathologyWan Fang HospitalTaipei Medical UniversityTaipei 11696Taiwan Department of PathologySchool of MedicineCollege of MedicineTaipei Medical UniversityTaipei 110Taiwan niChe Lab for Stem Cell and Regenerative MedicineDepartment of Biochemical Science and TechnologyNational Taiwan UniversityTaipei 10617Taiwan Institute of Polymer Science and EngineeringNational Taiwan UniversityTaipei 10617Taiwan 

出 版 物：《World Journal of Gastrointestinal Oncology》 (世界胃肠肿瘤学杂志（英文版）（电子版）)

年 卷 期：2022年第14卷第4期

页      面：748-764页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Regulatory RNAs MicroRNA Long-non coding RNA Circular RNA Colorectal cancer Cancer stem cell Stemness 

摘      要：The properties of cancer stem cells(CSCs),such as self-renewal,drug resistance,and metastasis,have been indicated to be responsible for the poor prognosis of patients with colon cancers.The epigenetic regulatory network plays a crucial role in CSC properties.Regulatory non-coding RNA(ncRNA),including microRNAs,long noncoding RNAs,and circular RNAs,have an important influence on cell physiopathology.They modulate cells by regulating gene expression in different ways.This review discusses the basic characteristics and the physiological functions of colorectal cancer(CRC)stem cells.Elucidation of these ncRNAs will help us understand the pathological mechanism of CRC progression,and they could become a new target for cancer treatment.