Pathophysiological mechanisms of hepatic stellate cells activation in liver fibrosis

作     者：Dmitry Victorovich Garbuzenko 

作者机构：Department of Faculty SurgerySouth Ural State Medical UniversityChelyabinsk 454092Russia 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2022年第10卷第12期

页      面：3662-3676页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Chronic liver disease Liver fibrosis Pathogenesis Hepatic stellate cells Activation Pathophysiological mechanisms 

摘      要：Liver fibrosis is a complex pathological process controlled by a variety of cells,mediators and signaling *** stellate cells play a central role in the development of liver *** chronic liver disease,hepatic stellate cells undergo dramatic phenotypic activation and acquire fibrogenic *** review focuses on the pathophysiological mechanisms of hepatic stellate cells activation in liver *** enter the cell cycle under the influence of various ***“Initiationphase of hepatic stellate cells activation overlaps and continues with the“Perpetuationphase,which is characterized by a pronounced inflammatory and fibrogenic *** is followed by a resolution phase if the injury *** of these pathophysiological mechanisms paved the way for drugs aimed at preventing the development and progression of liver *** this respect,impairments in intracellular signaling,epigenetic changes and cellular stress response can be the targets of therapy where the goal is to deactivate hepatic stellate *** antifibrotic therapy may focus on inducing hepatic stellate cells to return to an inactive state through cellular aging,apoptosis,and/or clearance by immune cells,and serve as potential antifibrotic *** is especially important to prevent the formation of liver cirrhosis since the only radical approach to its treatment is liver transplantation which can be performed in only a limited number of countries.