Studies on repairing of hemisected thoracic spinal cord of adult rats by using a chitosan tube filled with alginate fibers

作     者：LI Xiaoguang, YANG Zhaoyang and YANG Yi ( Beijing Center for Neural Regeneration and Repairing, Capital University of Medical Sciences, Beijing 100054, China Department of Bioengineering, Beijing University of Aeronautics and Astronautics, Beijing 100083, China National Center of Biomedical Analysis, Beijing 100850, China) 

作者机构：Beijing Center for Neural Regeneration and Repairing Capital University of Medical Sciences Beijing 100054 China Department of Bioengineering Beijing University of Aeronautics and Astronautics Beijing 100083 China National Center of Biomedical Analysis Beijing 100850 China 

出 版 物：《Progress in Natural Science:Materials International》 (自然科学进展·国际材料(英文))

年 卷 期：2006年第16卷第10期

页      面：1051-1055页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 0805[工学-材料科学与工程（可授工学、理学学位）] 071002[理学-动物学] 0702[理学-物理学] 

基　　金：Supported by National Natural Science Foundation of China (Grant No. 3033020) Nature Key Program of Beijing (Grant No. 7041002) Na-tional 863 Project (Grant No. 2005AA205) Key Project of Science and Technology of Beijing (Grant No. H020920040430) 

主　　题：spinal cord injury regeneration function recovery chitosan alginate behavioral evaluation. 

摘      要：A chitosan tube filled with alginate fibers was implanted into the injured spinal cord of a rat for repairing the damaged tissue. Twelve months after the operation, the morphological observation demonstrated that this chitosan tube could induce regeneration of myelinated and non-myelinated axons and blood vessels. The Basso-Beattie-Bresnahan (BBB) behavioral evaluation confirmed that the implants played a key role in the long-term restoration of rats motor functions. It is a promising start in the treatment of the patients with the injury of the spinal cord.