Mending a broken heart with novel cardiogenic small molecules

作     者：Nevan Powers Guo N.Huang 

作者机构：Cardiovascular Research Institute&Department of PhysiologyUniversity of CaliforniaSan FranciscoSan FranciscoCA 94158USA Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell ResearchUniversity of CaliforniaSan FranciscoSan FranciscoCA 94158USA 

出 版 物：《Cell Regeneration》 (细胞再生（英文）)

年 卷 期：2022年第11卷第1期

页      面：188-191页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：This work is supported by NIH(R01HL138456 and R01HL157280),American Heart Association Transformation Award Tobacco-Related Disease Research Program 

主　　题：cardio cardiac 

摘      要：Adult mammalian cardiomyocytes are unable to proliferate to regenerate lost tissue after heart *** et al.,reporting in Cell Stem Cell,employ a FUCCI-and MADM-based system to screen for small molecules combinations that produced a collaborative effect on cardiomyocyte cycling and *** authors generate a cocktail of five small molecules that increase cardiomyocyte proliferation and regeneration in vitro and in vivo with high efficiency,and explore its potential in cardiac regenerative repair after myocardial infarction through a new potential pathway for cardiomyocyte cell-cycle re-entry.