NSAIDs局部点眼治疗对Sjgren综合征患者角膜敏感性和眼表的影响

作     者：Aragona P. Stilo A. Ferreri F. Mobrici M. 杨秀梅 

作者机构：Viale Boccetta 70 Messina I-98122 Italy 

出 版 物：《世界核心医学期刊文摘（眼科学分册）》 (Digest of the World Core Medical Journals:Ophthalmology)

年 卷 期：2005年第1卷第9期

页      面：31-31页

学科分类：1002[医学-临床医学] 100212[医学-眼科学] 10[医学] 

主　　题：Sj gren 泪膜破裂时间 双氯芬酸钠 吲哚美辛 统计学分析 Student 

摘      要：Aim and purpose: To evaluate the effects of two NSAIDs on corneal sensitivity and ocular surface in Sj¨ogren’s syndrome (SS) patients. Methods: In all, 20 SS patients with epithelial corneal defects, were randomly divided into two groups: group 1 (10 females, age 35-63 years), treated with 0.1%indomethacin, one drop three times a day; group 2 (nine females, one male, age 38-65 years) treated with 0.1%diclofenac, at the same regimen. No systemic NSAIDs were allowed. Use of tear substitute was allowed. Corneal sensitivity, corneal staining, BUT, and ocular discomfort, were evaluated before and after 15, 30 days of treatment and 7 days after NSAID discontinuation. For statistical analysis, the Student’s t-test and Mann-WhitneyU test were used. Results: Both groups showed at day 30 a statistically significant reduction of corneal sensitivity (P 0.05), although the diclofenac-treated group showed a statistically significant lower sensitivity if compared to the indomethacin-treated group (P 0.05). Corneal fluorescein score showed a statistically significantly worst alteration in group 2, 7 days after the discontinuation of the therapy (P=0.02). The ocular discomfort score was statistically significantly reduced in both groups starting from day 15 (P 0.05). Discussion: The results indicate that NSAIDs can be useful in resolving symptoms of ocular discomfort in SS patients. However, they should be usedwith caution and under close monitoring, and the treatment should be promptly discontinued if corneal epithelial defects develop or worsen during treatment.