A likelihood-based method for haplotype association studies of case-control data with genotyping uncertainty

作     者：ZHU Wensheng GUO Jianhua 

作者机构：School of Mathematics and Statistics Northeast Normal University Changchun 130024 China School of Mathematics and Statistics Northeast Normal University Changchun 130024 China 

出 版 物：《Science China Mathematics》 (中国科学：数学（英文版）)

年 卷 期：2006年第49卷第1期

页      面：130-144页

核心收录：

学科分类：07[理学] 08[工学] 

基　　金：supported by the National Natural Science Foundation of China(Grant Nos.10431010&10371015) the National Science Foundating for Distinguished Young Scholars(Grant No.10329102) the Science and Technology Keystone Fund of MOE,China(Grant Nos.104070&00041) NCET-04-0310,EYTP and the Jilin Distinguished Young Scholars Program(Grant No.20030113) 

主　　题：haplotype-based association GenoSpectrum case-control study genotyping error logistic regres- 

摘      要：This paper discusses the associations between traits and haplotypes based on Fl (fluorescent intensity) data sets, We consider a clustering algorithm based on mixtures of t distributions to obtain all possible genotypes of each individual (i.e. GenoSpectrum). We then propose a likelihood-based approach that incorporates the genotyping uncertainty to assessing the associations between traits and haplotypes through a haplotypebased logistic regression model, Simulation studies show that our likelihood-based method can reduce the impact induced by genotyping errors.