NR4A1 agonist cytosporone B attenuates neuroinflammation in a mouse model of multiple sclerosis

作     者：Hai-Zhen Yu Bing-Qing Zhu Lin Zhu Shuo Li Li-Mei Wang Hai-Zhen Yu;Bing-Qing Zhu;Lin Zhu;Shuo Li;Li-Mei Wang

作者机构：Department of NeurologyThe First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2022年第17卷第12期

页      面：2765-2770页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China  Nos.U1804178(to LMW)and 31870334(to LZ) 

主　　题：cytosporone B(Csn-B) experimental autoimmune encephalomyelitis macrophages microglia multiple sclerosis NR4A1 agonist NR4A1 Th1 Th17 treatment 

摘      要：Nuclear receptor subfamily 4 group A1(NR4A1)is an orphan nuclear receptor,which is expressed in the majority of ***4A1 expression in peripheral blood mononuclear cells is low during the preclinical stage of multiple *** of the Nr4a1 gene in mice can aggravate the symptoms of experimental autoimmune encephalomyelitis(EAE),which is an animal model of multiple *** this study,we intragastrically administered the NR4A1 agonist cytosporone B(Csn-B)to mice after inducing *** treatment with Csn-B,the clinical symptoms in the EAE mice were substantially attenuated compared with that in PBS-treated control *** percentages of CD4+T cells and F4/80+cells in the central nervous system were *** addition,interferon-γand interleukin-17 production by proinflammatory Th1/Th17 cells in the central nervous system and interferon-γlevels in splenocytes were decreased after Csn-B *** findings suggest that the NR4A1 agonist Csn-B can alleviate nerve injury after EAE induction,and,therefore,may be useful as a potential treatment for multiple sclerosis.