Photoinduced and palladium-catalyzed hydrogen atom transfer triggered 1,2-difunctionalization of 1,3-dienes with hydroxamides

作     者：Xiao-Yun Ruan Tao Zhang Wen-Ao Li Yi-Zhuo Yin Zhi-Yong Han Liu-Zhu Gong Xiao-Yun Ruan;Tao Zhang;Wen-Ao Li;Yi-Zhuo Yin;Zhi-Yong Han;Liu-Zhu Gong

作者机构：Department of ChemistryUniversity of Science and Technology of ChinaHefei 230026China 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：2022年第65卷第5期

页      面：863-869页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：supported by the National Natural Science Foundation of China (22188101  21831007  21971231  21772184) 

主　　题：photoinduced palladium catalysis C–H activation hydrogen atom transfer 1,3-dienes allylation 

摘      要：The discovery of novel catalysis modes to generate a significant increase in structural complexity from readily available reactants is a fundamental goal in modern organic ***,we report a photoinduced palladium-catalyzed hydrogen atom transfer triggered 1,2-difunctionalization of conjugated *** the employment of exogeneous photosensitizers and external oxidants,the cascade reaction realized the integration of remote functionalization of various C(sp^(3))-H bonds and selective difunctionalization of 1,3-dienes with 100% atom efficiency,allowing for the synthesis of structurally diverse amides with up to 90% *** the prevalence of amides in pharmaceuticals and natural products,the current protocol has provided an efficient means to access highly functionalized amides from readily available carboxylic acid derivatives and 1,3-dienes.