Organogels, hydrogels and bigels as transdermal delivery systems for diltiazem hydrochloride

作     者：Mahmoud Mokhtar Ibrahim Salma A.Hafez Mahmoud M.Mahdy 

作者机构：Department of PharmaceuticsFaculty of pharmacyZagazig UniversityZagazigEgypt Department of PharmaceuticsFaculty of PharmacyNajran UniversityNajranSaudi Arabia 

出 版 物：《Asian Journal of Pharmaceutical Sciences》 (亚洲药物制剂科学（英文）)

年 卷 期：2013年第8卷第1期

页      面：48-57页

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070305[理学-高分子化学与物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 

主　　题：Organogels Hydrogels Bigels Lecithin Span 

摘      要：In the present study,gel formulations of organogels,hydrogels,and oleo-hydrogel(bigels)were evaluated as transdermal drug delivery systems for diltiazem HCL(DH).Organogels were prepared using soya-bean oil(SO)as a solvent and span 60(Sp 60),cetyl alcohol(CA)or lecithinpluronic(PLO)as organogelators without and with different surfactants(2%w/w)namely span 80(Sp80),tween 20(T20)and tween 80(T80).On the other hand,hydrogels were formulated using Hydroxypropyl-methylcellulose(HPMC)polymer and bigels were prepared by mixing organogels with HPMC *** prepared gels were analyzed microscopically,thermally by DTA and for pH,and *** effect of gelator used,surfactant types and pH of the sink on DH release from cellophane membrane was *** addition,the DH permeability across the rabbit skin was ***,the in vivo performance of various gel formulationswas assessed based on the hypotensive effects of the drug using hypertensive albino male rat *** microscopical analysis indicated that the solid fibers formed by gelator particles form the backbone of the organogels while bigels appeared as emulsion *** addition of surfactants showed an increase in organogel *** thermal analysis of organogels indicated that the drug present in amorphous not in crystalline *** release studies indicated that DH release from organogels,hydrogels and bigels could be *** included surfactants decreased the DH release and permeation from organogels compared to those without surfactants using either Sp60 or *** hydrogel and Bigels showed higher DH release and permeation rates when compared to *** percent DH released in different pH values was in the following descending order:pH5.5pH1.2pH6.8*** in vivo antihypertensive activity of DH using different transdermal gels is arranged as following:hydrogelsPLO organogelbigelSp 60 organogel.