Studies on the Mechanism of Primary Nucleation of Ciprofloxacin Hydrochloride Monohydrate

作     者：王静康 刘勇 尹秋响 

作者机构：SchoolofChemicalEngineeringandTechnologyTianjinUniversityTianjin300072China 

出 版 物：《Chinese Journal of Chemical Engineering》 (中国化学工程学报（英文版）)

年 卷 期：2002年第10卷第4期

页      面：375-380页

核心收录：

学科分类：081704[工学-应用化学] 08[工学] 0817[工学-化学工程与技术] 081701[工学-化学工程] 

主　　题：ciprofloxacin hydrochloride monohydrate induction period primarynucleation diffusion growth 

摘      要：A general expression for the relationship between induction periodand supersaturation was developed based on polynuclear *** mechanism of primary nucleation in solution can beillustrated by the expression. The results of induction perioddetermined by laser scattering method shows that the crystallizationof ciprofloxacin hydrochloride monohydrate in water/ethanol oraqueous solution is by the mechanism of primary nucleation followedby one-dimensional diffusion growth, and then on-dimensionalcontinuous or birth and spread growth on crystal face. The growthmechanism on the crystal face is affected by temperature and solvent.