Commensal microbiota in the digestive tract:a review of its roles in carcinogenesis and radiotherapy

作     者：Jiali Dong Yuan Li Huiwen Xiao Ming Cui Saijun Fan Jiali Dong;Yuan Li;Huiwen Xiao;Ming Cui;Saijun Fan

作者机构：Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear MedicineInstitute of Radiation MedicineChinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin 300192China Department of MicrobiologyCollege of Life SciencesNankai UniversityTianjin 300071China 

出 版 物：《Cancer Biology & Medicine》 (癌症生物学与医学（英文版）)

年 卷 期：2022年第19卷第1期

页      面：43-55页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 08[工学] 

基　　金：supported by grants from the Science Foundation for Distinguished Young Scholars of Tianjin(Grant No.20JCJQJC00100) the National Natural Science Foundation of China(Grant Nos.81572969,81730086 and 81872555) the Drug Innovation Major Project of China(Grant No.2018ZX09711001-007-008) the PUMC Graduate Innovation Fund(Grant No.2018-1001-04 and 2019-1001-06)。 

主　　题：Oral microbiome gut microbiome cancer radiotherapy 

摘      要：The human microflora is a complex ecosystem composed of diverse microorganisms mainly distributed in the epidermal and mucosal habitats of the entire body,including the mouth,lung,intestines,skin,and vagina.These microbial communities are involved in many essential functions,such as metabolism,immunity,host nutrition,and diseases.Recent studies have focused on the microbiota associated with cancers,particularly the oral and intestinal microbiota.Radiotherapy,the most effective cytotoxic modality available for solid tumors,contributes to the treatment of cancer patients.Mounting evidence supports that the microbiota plays pivotal roles in the efficacy and prognosis of tumor radiotherapy.Here,we review current research on the microbiota and cancer development,and describe knowledge gaps in the study of radiotherapy and the microbiota.Better understanding of the effects of the microbiome in tumorigenesis and radiotherapy will shed light on future novel prevention and treatment strategies based on modulating the microbiome in cancer patients.