Gut microbiota-derived short chain fatty acids are potential mediators in gut inflammation

作     者：Muhammad Akhtar Yan Chen Ziyu Ma Xiaolong Zhang Deshi Shi Jawaria AKhan Huazhen Liu Muhammad Akhtar;Yan Chen;Ziyu Ma;Xiaolong Zhang;Deshi Shi;Jawaria A.Khan;Huazhen Liu

作者机构：Department of Basic Veterinary MedicineCollege of Animal Science and Veterinary MedicineHuazhong Agricultural UniversityWuhan430070China Department of Preventive Veterinary MedicineCollege of Animal Science and Veterinary MedicineHuazhong Agricultural UniversityWuhan430070China Department of Veterinary MedicineFaculty of Veterinary ScienceUniversity of Veterinary and Animal SciencesLahore54000Pakistan 

出 版 物：《Animal Nutrition》 (动物营养（英文版）)

年 卷 期：2022年第8卷第1期

页      面：350-360页

核心收录：

学科分类：1002[医学-临床医学] 0905[农学-畜牧学] 0906[农学-兽医学] 10[医学] 

基　　金：The National Key Research and Development Program of China(2017YFE0113700) the Hubei Provincial Natural Science Foundation of China(2017CFB514) the National Natural Science Foundation of China(30800808). 

主　　题：Gut microbiota Short chain fatty acid Gut inflammation Gut homeostasis Inflammatory bowel disease 

摘      要：Gut inflammation is a challenging concern in humans and animals,which disturbs normal growth and leads to severe bowel diseases.Short chain fatty acids(SCFA)are the gut microbiota metabolites produced from fermentation of non-digestible carbohydrates,and have been reported to modulate gut inflammation.SCFA have been implicated as the potential therapeutic bioactive molecules for gut inflammatory diseases,and could be an alternative to antibiotic growth promoters(AGP).In this review,the existing knowledge about the types of SCFA,the related gut microbes producing SCFA,the roles of SCFA in maintaining gut homeostasis,and how SCFA modulate gut inflammation is summarized.The therapeutic application of SCFA in the treatment of inflammatory bowel disease(IBD)is also highlighted