Carboxytherapy and Platelet Rich Plasma： A New Therapy for Trigonitis, Abacterial and Interstitial Cystitis
Carboxytherapy and Platelet Rich Plasma： A New Therapy for Trigonitis, Abacterial and Interstitial Cystitis作者机构：Department of Urology and Oncologic Urology S. Eugenio Hospital Rome 00144 Rome Italy
出 版 物：《Journal of Pharmacy and Pharmacology》 (药剂与药理学（英文版）)
年 卷 期：2015年第3卷第9期
页 面：405-410页
学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学]
主 题：Carboxytherapy platelet rich plasma cystitis trigonitis interstitial cystitis.
摘 要：Cystitis often appears even in absence of bacteria colonization. Trigonitis and interstitial inflammation are the most common morphological features of abacterial cystitis in young and post menopausal women. Arterial obstructive disease and bladder ischemia might play an important role in bladder dysfunction. Activated inflammatory cells produce ROS （radicals of oxygen）, NF kB seems involved in ROS synthesis. Clinical studies have indicated that high CO2 levels can impact upon peripheral tissue, reducing ischaemia, responsible of recurrent inflammation and consequently reducing oxydative phenomena. PRP （platelet-rich plasma） is a volume of fractionated plasma from the patient＇s own blood that contains platelet concentrate rich of alpha granules. PRP interacts tissue repair mechanisms by placing supra-physiological concentrations of autologous platelets at the site of tissue damage. This study proposes a single PRP transvaginal injection followed by 10 weekly applications of carboxytherapy, using subcutaneous injections of sterile CO2 gas. We have selected 6 Women （50-75 years）, affected by recurrent abacterial cystitis with Pain and urge incontinence. All patients showed a subjective sensible reduction of symptoms. After 2 months all patients have neither inflammatory symptoms nor endoscopic evidence of trigonitis. Preliminary qualitative results could encourage the use of carboxytherapy and PRP in treatment of abacterial and interstitial cystitis.
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