A Lindqvist-type [W_(6)O_(19)]^(2-) organic–inorganic compound: synthesis, characterization, antibacterial activity and preliminary studies on the mechanism of action

作     者：Meng Zhao Xi-Yu Zhu Yan-Zhen Li Jiang-Nan Chang Ming-Xue Li Li-Hua Ma Xiao-Yuan Guo 

作者机构：Henan Key Laboratory of Polyoxometalate ChemistryInstitute of Molecular and Crystal EngineeringSchool of Chemistry and Chemical EngineeringHenan UniversityKaifeng475004China Agricultural Products’Quality and Safety Testing Center of KaifengKaifeng Agriculture and Rural BureauHenan475004China 

出 版 物：《Tungsten》 (钨科技（英文）)

年 卷 期：2022年第4卷第2期

页      面：121-129页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 0703[理学-化学] 10[医学] 

基　　金：financially supported by the National Natural Science Foundation of China (Grant No.21671055) Henan University First-class Discipline Cultivation Project (Grant No.2020YLZDYJ06) Medical Interdisciplinary Training Program of Henan University of China (Grant No.CJ1205A0240007) the Scientific and Technological Project of Henan province (Grant No. 212102310852) 

主　　题：Isopolytungstate Thiosemicarbazone Bioactivity Mechanism of action 

摘      要：In this paper,a new organic–inorganic hybrid compound[Co(L)_(2)]2[W_(6)O_(19)](1)(HL=2-acetylpyridine thiosemicarbazone)was prepared and *** compound 1 exhibits remarkable antibacterial activity by determination of minimum inhibitory concentration(MIC)against Staphylococcus aureus(***,0.06μg·mL^(−1))and Escherichia coli(***,0.24μg·mL^(−1)),***,the potential mechanism of compound 1 was studied in *** potential causes of bacteria death were cell wall/membrane disruption,inhibition of intracellular respiratory chain dehydrogenases(RCD)activity,destruction of reactive oxygen species(ROS)and depletion of glutathione(GSH).