Involvement and therapeutic implications of airway epithelial barrier dysfunction in type 2 inflammation of asthma

作     者：Xiang Dong Mei Ding Jinjin Zhang Ismail Ogülür Yagiz Pat Mübeccel Akdis Yadong Gao Cezmi A.Akdis Xiang Dong;Mei Ding;Jinjin Zhang;Ismail Ogülür;Yagiz Pat;Mübeccel Akdis;Yadong Gao;Cezmi A. Akdis

作者机构：Department of AllergologyZhongnan Hospital of Wuhan UniversityHubei Province Key Laboratory of Allergy and ImmunologyWuhanHubei 430071China Swiss Institute of Allergy and Asthma Research(SIAF)University of ZurichHerman-Burchard Strasse 9DavosSwitzerland. 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2022年第135卷第5期

页      面：519-531页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

主　　题：Airway epithelial barrier Type 2 inflammation Asthma Allergen Environmental pollutants 

摘      要：Type 2 inflammation is a complex immune response and primary mechanism for several common allergic diseases including allergic rhinitis,allergic asthma,atopic dermatitis,and chronic rhinosinusitis with nasal polyps.It is the predominant type of immune response against helminths to prevent their tissue infiltration and induce their expulsion.Recent studies suggest that epithelial barrier dysfunction contributes to the development of type 2 inflammation in asthma,which may partly explain the increasing prevalence of asthma in China and around the globe.The epithelial barrier hypothesis has recently been proposed and has received great interest from the scientific community.The development of leaky epithelial barriers leads to microbial dysbiosis and the translocation of bacteria to inter-and sub-epithelial areas and the development of epithelial tissue inflammation.Accordingly,preventing the impairment and promoting the restoration of a deteriorated airway epithelial barrier represents a promising strategy for the treatment of asthma.This review introduces the interaction between type 2 inflammation and the airway epithelial barrier in asthma,the structure and molecular composition of the airway epithelial barrier,and the assessment of epithelial barrier integrity.The role of airway epithelial barrier disruption in the pathogenesis of asthma will be discussed.In addition,the possible mechanisms underlying the airway epithelial barrier dysfunction induced by allergens and environmental pollutants,and current treatments to restore the airway epithelial barrier are reviewed.