Bioinformatic approach for understanding the heterogeneity of cholangiocytes

作     者：Koji Fukushima Yoshiyuki Ueno 

作者机构：Division of Gastroenterology Tohoku University Graduate School of MedicineSeiryoAobakuSendai980-8574Japan 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2006年第12卷第22期

页      面：3481-3486页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Health and Labour Sciences Research Grants from the Ministry of Health  Labour and Welfare of Japan for the Research on Measures for Intractable Diseases and GRANT-IN-AID FOR SCIENTIFIC RESEARCH C (16590573) from JSPS 

主　　题：Cholangiocytes Heterogeneity 

摘      要：It is remarkable that microarray technologies have nearly reached a pinnacle. Establishment of further analysis and management of enormous data derived from microarray technology is currently the highest priority. The heterogeneous functions of cholangiocytes regulate the pathophysiology of the biliary epithelium in relation to secretory, proliferative and apoptotic activities. Distinct expression profiles of two murine cholangiocyte lines, termed small and large have been revealed by microarray analysis. The features of the two cholangiocyte cell lines, categorized partly according to gene ontology, indicate the specific physiological role of each cell line. The large cholangiocytes are characterized as “transport and “immune/ inflammatory responses In contrast, small cholangiocytes are associated with properties of limited physiological functional ability and proliferating/migrating potential with specific molecules like Eph receptors, comparable to mesenchymal cells. ＇Omic study will be of great help in understanding the heterogeniety of cholangiocytes.