Effects of emodin and baicalein on rats with severe acute pancreatitis

作     者：Xi-PingZhang Zhong-FangLi Xiao-GongLiu Yong-TaoWu Jun-XianWang Kang-MinWang Yi-FengZhou 

作者机构：DepartmentofGeneralSurgeryFirstPeople'sHospitalofHangzhouHangzhou310006ZhejiangProvinceChina DepartmentofGeneralSurgerySecondHospitalofXi'anJiaotongUniversityXi'an710004ShaanxiProvinceChina PharmaceuticalCollegeofXi'anJiaotongUniversityXi'an710016ShaanxiProvinceChina DepartmentofPathologySecondHospitalofXi'anJiaotongUniversityXi'an710004ShaanxiProvinceChina DepartmentofDigestionFirstPeople'sHospitalofHangzhouHangzhou310006ZhejiangProvinceChina 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2005年第11卷第14期

页      面：2095-2100页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：Supported by the National Natural Science Foundation of China No. 30171167 

主　　题：Emodin Severe acute pancreatitis 

摘      要：AIM: To investigate the therapeutic effects of emodin in combination with baicalein on severe acute pancreatitis (SAP) rats and to explore the mechanism of SAP. METHODS: A total of 112 SAP rats induced by retrograde injection of 5% sodium taurocholate into the biliarypancreatic duct, randomly assigned to a untreated group and three treated groups emodin group, combined emodin and baicalein group, and sandostatin group. Meanwhile, another 28 other rats were selected as sham operation (SO) group. There were 28 rats in each group, 8 rats were in 3 and 6 h groups respectively, and 12 rats in 12 h group. At each time-points, survival rates, ascites volumes, pathological lesion scores of pancreas tissues, serum amylase, tumor necrosis factor-α and IL-6 levels were determined as the indexes of therapeutic effects. RESULTS: The survival rate at 12 h was significantly higher in three treated groups than in untreated group. The ascites volume at 12 h was remarkably less in combined and sandostatin groups than in emodin group, but there was no difference between combined group and sandostatin group (P0.05). Serum amylase levels at all time-points were significantly lower in three treated groups than in untreated group. However, they had no difference among treated groups (P0.05). Serum TNF-α were lower in three treated groups than in untreated group at all time points. Among the three treated groups, at 6 h, the TNF-α levels of combination and sandostatin groups were lower than those of emodin group. These was no difference between combined and sandostantin. Serum IL-6 concentration at 3 h were lower in combined and sandostatin groups than in untreated group, but at 6 and 12 h they were lower in all treated groups than in untreated group and the combined and sandostatin groups and in emodin group, no difference was found between combined and sandostatin groups at all time-points (P0.05). The pathological scores of pancreas at all time points were significantly lower in thre