Targeting non-coding RNAs to overcome cancer therapy resistance

作     者：BaoQing Chen Mihnea P.Dragomir Chen Yang Qiaoqiao Li David Horst George A.Calin 

作者机构：Department of Radiation OncologyState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhouGuangdong 510060China Institute of PathologyCharité-Universitätsmedizin Berlincorporate member of Freie Universität BerlinHumboldt-Universität zu Berlin and Berlin Institute of HealthBerlin 10117Germany Berlin Institute of HealthAnna-Louisa-Karsch-Straße 210178 BerlinGermany German Cancer Consortium(DKTK)Partner Site BerlinGerman Cancer Research Center(DKFZ)69210 HeidelbergGermany Department of Translational Molecular PathologyThe University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Center for RNA Interference and Non-Coding RNAsThe University of Texas MD Anderson Cancer CenterHoustonTX 77030USA 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2022年第7卷第5期

页      面：1447-1466页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：We thank Bryan Tutt,Scientific Editor,Research Medical Library,MDACC for editorial support.The work of B.C.is supported by National Natural Science Foundation of China(No.81902462) M.P.D.is a participant in the BIH-CharitéJunior Clinical Scientist Program funded by the Charité–Universitätsmedizin Berlin and the Berlin Institute of Health.G.A.C.is the Felix L.Haas Endowed Professor in Basic Science.Work in G.A.C.’s laboratory is supported by NCI grants 1R01 CA182905-01 and 1R01CA222007-01A1,NIGMS grant 1R01GM122775-01,DoD Idea Award W81XWH2110030,a Team DOD grant in Gastric Cancer,a Chronic Lymphocytic Leukemia Moonshot Flagship project,a CLL Global Research Foundation 2019 grant,a CLL Global Research Foundation 2020 grant The G.Harold&Leila Y.Mathers Foundation,a grant from Torrey Coast Foundation,and an Institutional Research Grant and Development Grant associated with the Brain SPORE 2P50CA127001 

主　　题：chemotherapy metastasis RNAs 

摘      要：It is now well known that non-coding RNAs(ncRNAs),rather than protein-coding transcripts,are the preponderant RNA ***,particularly microRNAs(miRNAs),long non-coding RNAs(lncRNAs),and circular RNAs(circRNAs),are widely appreciated as pervasive regulators of multiple cancer hallmarks such as proliferation,apoptosis,invasion,metastasis,and genomic *** recent discoveries in cancer therapy,resistance to chemotherapy,radiotherapy,targeted therapy.