Synthesis of Unsymmetric Ureas by Selenium-Catalyzed Oxidative-Reductive Carbonylation with CO
Synthesis of Unsymmetric Ureas by Selenium-Catalyzed Oxidative-Reductive Carbonylation with CO作者机构：National Engineering Research Center for Catalysis Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 Dalian Naval Institute 696 Jiefang Road Dalian 116018 National Engineering Research Center for Catalysis Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023
出 版 物：《有机化学》 (Chinese Journal of Organic Chemistry)
年 卷 期：2003年第23卷第Z1期
页 面：69-70页
核心收录：
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
主 题：biological activities phase separation nitro compounds peptide bond instead of
摘 要： Unsymmetric, substituted ureas that contain the peptide bond (NHCONH), many of which possess biological activities, are widely used as herbicides, agrochemicals and pharmaceuticals. [1,2] A series of unsymmetric ureascontaining substituted groups have been synthesized via selenium-catalyzed selective oxidative-reductive carbonylation of amines and nitro compounds with CO instead of phosgene in one-pot reaction. [3,4] These catalytic reactions are important from both synthetic and industrial points of view, because not only the reactions can be proceeded with high selectivity of higher than 99% towards desired unsymmetric ureas, but also there exists a phase-transfer process of the selenium catalyst in thereaction, so that the after-treatment of the catalysts and products from the reaction systems can be easily separated by simple phase separation.……
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