The horizon of bone organoid: A perspective on constructionand application
作者机构：Institute of Translational MedicineShanghai UniversityShanghai200444China Department of Orthopaedics TraumaChanghai HospitalSecond Military Medical UniversityShanghai200433China
出 版 物：《Bioactive Materials》 (生物活性材料（英文）)
年 卷 期：2022年第7卷第12期
页 面：15-25页
核心收录：
学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 08[工学] 0836[工学-生物工程] 10[医学]
基 金：the National Key Research and Development Plan(2018YFC2001500) National Natural Science Foundation of China(82172098,81972254,81871099,32101084) Shanghai Rising-Star Program(21QA1412000)
主 题：Bone organoid Bone regeneration Scaffold Disease models
摘 要：Bone defects repair and regeneration by various causes such as tumor resection, trauma, degeneration, etc. havealways been a key issue in the clinics. As one of the few organs that can regenerate after adulthood, bone itselfhas a strong regenerative ability. In recent decades, bone tissue engineering technology provides various types offunctional scaffold materials and seed cells for bone regeneration and repair, which significantly accelerates thespeed and quality of bone regeneration, and many clinical problems are gradually solved. However, the bonemetabolism mechanism is complicated, the research duration is long and difficult, which significantly restrictsthe progress of bone regeneration and repair research. Organoids as a new concept, which is built in vitro withthe help of tissue engineering technology based on biological theory, can simulate the complex biologicalfunctions of organs in vivo. Once proposed, it shows broad application prospects in the research of organdevelopment, drug screening, mechanism study, and so on. As a complex and special organ, bone organoidconstruction itself is quite challenging. This review will introduce the characteristics of bone microenvironment,the concept of organoids, focus on the research progress of bone organoids, and propose the strategies for boneorganoid construction, study direction, and application prospects.
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