Microbial resistance to nanotechnologies:An important but understudied consideration using antimicrobial nanotechnologies in orthopaedic implants

作     者：Zhuoran Wu Brian Chan Jessalyn Low Justin Jang Hann Chu Hwee Weng Dennis Hey Andy Tay 

作者机构：Institute of Health Innovation&TechnologyNational University of Singapore117599Singapore Department of Biomedical EngineeringNational University of Singapore117583Singapore Biosafety Level 3 Core FacilityYong Loo Lin School of MedicineNational University of Singapore117599Singapore Department of Microbiology and ImmunologyYong Loo Lin School of MedicineNational University of Singapore117545Singapore Infectious Disease ProgrammeYong Loo Lin School of MedicineNational University of Singapore117547Singapore Institute of Molecular and Cell Biology35 Agency for ScienceTechnology and Research138673Singapore National University Health SystemNational University of Singapore119228Singapore Tissue Engineering ProgrammeNational University of Singapore117510Singapore 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2022年第7卷第10期

页      面：249-270页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 08[工学] 0836[工学-生物工程] 10[医学] 

基　　金：funding support from the NUS Presidential Young Professorship and NUS Technological Innovations in Infectious Diseases Translational Research 

主　　题：Bacterial infection Orthopaedic implant Microbial resistance Nanomaterial Antimicrobial nanotechnology 

摘      要：Microbial resistance to current antibiotics therapies is a major cause of implant failure and adverse clinical outcomes in orthopaedic *** developments in advanced antimicrobial nanotechnologies provide numerous opportunities to effective remove resistant bacteria and prevent resistance from occurring through unique *** tunable physicochemical properties,nanomaterials can be designed to be bactericidal,antifouling,immunomodulating,and capable of delivering antibacterial compounds to the infection region with spatiotemporal *** its substantial advancement,an important,but under-explored area,is potential microbial resistance to nanomaterials and how this can impact the clinical use of antimicrobial *** review aims to provide a better understanding of nanomaterial-associated microbial resistance to accelerate bench-to-bedside translations of emerging nanotechnologies for effective control of implant associated infections.