Effect of Wuda granule on gastrointestinal function recovery after laparoscopic intestinal resection:a randomized–controlled trial

作     者：Haiping Zeng Wei Wang Lixing Cao Yuyan Wu Wenwei Ouyang Dechang Diao Jin Wan Qicheng Chen Zhiqiang Chen 

作者机构：The Second School of Clinical MedicineGuangzhou University of Chinese MedicineGuangzhouGuangdongP.R.China Center of TCM applications PerioperativeGuangdong Provincial Hospital of Chinese MedicineGuangzhouGuangdongP.R.China Department of Gastrointestinal SurgeryGuangdong Provincial Hospital of Chinese MedicineGuangzhouGuangdongP.R.China Key Unit of Methodology in Clinical ResearchThe Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhouGuangdongP.R.China Department of Global Public HealthKarolinska InstituteStockholmSweden Department of Colorectal SurgeryGuangdong Provincial Hospital of Chinese MedicineGuangzhouGuangdongP.R.China 

出 版 物：《Gastroenterology Report》 (胃肠病学报道（英文）)

年 卷 期：2022年第10卷第1期

页      面：257-264页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：supported by the Special Subsidy for Clinical Research of Guangdong Hospital of Traditional Chinese Medicine[grant number YN10101902] the Double First-Class and High-level University Discipline Collaborative Innovation Team Project of Guangzhou University of Chinese Medicine[grant number 2021xk48] 

主　　题：Wuda granule laparoscopic intestinal resection post-operative gastrointestinal function ERAS 

摘      要：Background Previous studies have suggested that the Wuda granule(WDG)could promote the recovery of gastrointestinal(GI)function after gynecologic abdominal *** trial aimed to investigate the efficacy and safety of WDG in the rapid recovery of GI function in patients after laparoscopic intestinal resection in the setting of enhanced recovery after surgery(ERAS)-based perioperative *** We performed a randomized,double-blind,placebo-controlled pilot *** patients who met the inclusion criteria were randomly assigned to either the WDG group or the placebo group in a 1:1 *** patients received WDG or placebo twice a day in addition to ERAS-based perioperative care,starting on post-operative Day 1 until Day *** primary outcomes were time to first bowel movement and time to first tolerance of solid *** secondary outcomes were time to first flatus,length of hospital stay(LOS),and post-operative ileus-related *** events were also *** There were no statistically significant differences in baseline characteristics between the two *** median time to first bowel movement was significantly decreased in the WDG group compared with the control group(27.6 vs 50.1 h;P0.05)and LOS(5.0 vs 5.0 days;P0.05)were not statistically *** occurrence rates of post-operative nausea,vomiting,abdominal distension,and abdominal pain were similar in the two *** adverse events occurred in any *** The addition of WDG to ERAS post-operative care after laparoscopic intestinal resection can safely promote the rapid recovery of GI function.