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Synthesis,Crystal Structure and DNA-Binding Property of a New Cu(Ⅱ) Complex Based on 4-(Trifluoro-methyl)nicotinic Acid

Synthesis, Crystal Structure and DNA-Binding Property of a New Cu(Ⅱ) Complex Based on 4-(Trifluoro-methyl)nicotinic Acid

作     者:单凤琳 宋欢 高学智 李冰 麻晓霞 SHAN Feng-Lin;SONG Huan;GAO Xue-Zhi;LI Bing;MA Xiao-Xia

作者机构:State Key Laboratory of High-efficiency Utilization of Coal and Green Chemical EngineeringNingxia UniversityYinchuan 750021China Department of Chemistry&Chemical EngineeringNingxia UniversityYinchuan 750021China 

出 版 物:《Chinese Journal of Structural Chemistry》 (结构化学(英文))

年 卷 期:2022年第41卷第2期

页      面:57-63,I0008页

核心收录:

学科分类:07[理学] 070303[理学-有机化学] 0703[理学-化学] 

基  金:Supported by the National Natural Science Foundation of China (No. 21763022)。 

主  题:4-(trifluoro-methyl)nicotinic acid crystal structure DNA 

摘      要:A new complex[Cu_(1.5)(tfc)_(3)(H_(2)O)_(4)]·3H_(2)O (1,Htfc=4-(trifluoro-methyl) nicotinic acid) has been synthesized and characterized by X-ray single-crystal diffraction,elemental analysis,IR spectra and thermogravimetric analysis.1 belongs to orthorhombic system,space group Pccn with a=44.507(2),b=10.7710(6),c=11.7544(7)?,V=5634.9(6)?^(3),Z=1,D_(c)=1.803 mg·cm^(-3),F(000)=3068,μ=1.266 mm^(-1),the final R=0.0488and w R=0.1103 with I2σ(I).The Cu(II) ion is coordinated by two N and two O atoms from different Htfc as well as two O atoms from two coordinated water molecules,forming a 0D motif with distorted octahedral geometry.The adjacent 0D units are linked into 2D structures through bridge connection coordination mode.In addition,the binding properties of the complex with CT-DNA were investigated by fluorescence and ultraviolet spectra.UVspectra indicate classical intercalation between the complex and CT-DNA.Moreover,the interactions between the ligand and the complex with CT-DNA were studied by Et Br fluorescence probe,which proved that these compounds bind to CT-DNA through an intercalation mode.The binding constants were 0.76 and 1.15 for Htfc and complex 1,which means 1 has stronger interaction with CT-DNA than Htfc.

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