Novel oncogenes and tumor suppressor genes in hepatocellular carcinoma

作     者：Fang Wang Peter Breslin S J Wei Qiu Fang Wang;Peter Breslin S J;Wei Qiu

作者机构：Department of Surgery and Cancer BiologyLoyola University Chicago Stritch School of MedicineMaywoodILUSA Department of Molecular/Cellular PhysiologyCancer BiologyCardinal Bernardin Cancer CenterLoyola University Medical Centerand BiologyLoyola University ChicagoChicagoILUSA 

出 版 物：《Liver Research》 (肝脏研究（英文）)

年 卷 期：2021年第5卷第4期

页      面：195-203页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by (W. Qiu) from the American Cancer Society (W. Qiu) from the National Cancer Institute 

主　　题：Hepatocellular carcinoma(HCC) Oncogene Tumor suppressor Activation Loss-of-function 

摘      要：Hepatocellular carcinoma(HCC)is a very deadly disease.HCC initiation and progression involve multiple genetic events,including the activation of proto-oncogenes and disruption of the function of specific tumor suppressor genes.Activation of oncogenes stimulates cell growth and survival,while loss-of-function mutations of tumor suppressor genes result in unrestrained cell growth.In this review,we summarize the new findings that identified novel proto-oncogenes and tumor suppressors in HCC over the past five years.These findings may inspire the development of novel therapeutic strategies to improve the outcome of HCC patients.