Future perspective of focal therapy for localized prostate cancer
作者机构：Urologic Oncology BranchNational Cancer InstituteNational Institutes of HealthBethesdaMDUSA College of MedicineThe Pennsylvania State UniversityHersheyPAUSA Department of UrologyUniversity of MichiganAnn ArborMIUSA Center for Image-Guided and Focal Therapy for Prostate CancerInstitute of Urology and Catherine and Joseph Aresty Department of UrologyKeck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Institute of Urology and Catherine and Joseph Aresty Department of UrologyKeck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA
出 版 物：《Asian Journal of Urology》 (亚洲泌尿外科杂志（英文）)
年 卷 期：2021年第8卷第4期
页 面：354-361页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Focal therapy Prostate cancer Multiparametric magnetic resonance imaging Imaging Innovation Technology
摘 要：Objective:To summarize the recent literature discussing focal therapy for localized prostate cancer.Methods:A thorough literature review was performed using PubMed to identify recent studies involving focal therapy for the treatment of localized prostate cancer.Results:In an effort to decrease the morbidity associated with prostate cancer treatment,many urologists are turning to focal therapy as an alternative treatment option.With this approach,the cancer bearing portion of the prostate is targeted while leaving the benign tissue untouched.Multiparametric magnetic resonance imaging remains the gold standard for visualization during focal therapy,but new imaging modalities such as prostate specific membrane antigen/positron emission tomography and contrast enhanced ultrasound are being investigated.Furthermore,several biomarkers,such as prostate cancer antigen 3 and prostate health index,are used in conjunction with imaging to improve risk stratification prior to focal therapy.Lastly,there are several novel technologies such as nanoparticles and transurethral devices that are under investigation for use in focal therapy.Conclusion:Focal therapy is proving to be a promising option for the treatment of localized prostate cancer.However,further study is needed to determine the true efficacy of these exciting new technologies.
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