Synthesis of oleanolic disaccharide derivatives

作     者：Shu Chen Pei Jian Bo Wu Fan Lei Shan Qian Li Hai Yong Wu Shu Chen Pei;Jian Bo Wu;Fan Lei;Shan Qian;Li Hai;Yong Wu

作者机构：Key Laboratory of Drug Targeting and Drug Delivery System of the Education MinistryDepartment of Medicinal ChemistryWest China School of PharmacySichuan UniversityChengdu 610041China Bioengineering CollegeXihua UniversityChengdu 610039China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2012年第23卷第4期

页      面：403-406页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 081703[工学-生物化工] 08[工学] 0817[工学-化学工程与技术] 0836[工学-生物工程] 082203[工学-发酵工程] 0822[工学-轻工技术与工程] 10[医学] 

基　　金：supported by the National Natural Sciences Foundation of China(No.81072532) Scientific Research Fund of Sichuan Provincial Education Department(No.11205023) 

主　　题：Oleanolic acid Rhamnopyranosyl Arabinopyranosyl Anti-tumor Association principle 

摘      要：Oleanolic acid 1 exists widely in food,medicinal herbs and other plants and possesses many attractive biological activities. Recently,some oleanolic derivatives were reported to have interesting anti-tumor ***,using association principle of drug design,OA disaccharide 17 was designed and synthesized by coupling a-L-rhamnopyranosyl-（1→2）-a-L-arabinopyranosyl disaccharide moiety,which has proved to be a unique sugar sequence with strongly antitumor activity,and modified OA with a nitrile at C-17.