对于传统治疗方法耐受的Behcet病患者玻璃体腔内重复注射曲安奈德的1年研究结果

作     者：Ohguro N. Yamanaka E. Otori Y. 王海燕 

作者机构：Dr.Department of Ophthalmology Osaka University Medical School Osaka Japan 

出 版 物：《世界核心医学期刊文摘(眼科学分册)》 (Digest of the World Core Medical Journals)

年 卷 期：2006年第4期

页      面：14-15页

学科分类：1002[医学-临床医学] 100212[医学-眼科学] 10[医学] 

主　　题：玻璃体腔 Behcet 曲安奈德 耐受 治疗方法 重复注射 患者 

摘      要：PURPOSE: To determine whether repeated intravitreal triamcinolone (IVTA) injections in patients with Behet disease that is resistant to conventional therapy will prevent recurrences of uveitis. DESIGN: Prospective preliminary clinical trial. METHODS: Nine eyes of five patients with Behet disease with sight-threatening uveitis that was resistant to conventional therapy received repeated IVTA injections. Each patient was examined monthly, and IVTA was given when the TA particles that remained in the vitreous were judged to be gone before the next visit. RESULTS: Repeated IVTA completely prevented the recurrence of uveitis in eight eyes, and the one eye that had an attack experienced the uveitis when the TA particles disappeared quicker than expected. It was possible to stop systemic corticosteroid and/or immunosuppressive agents within 1 year after IVTA in three patients. CONCLUSION: These results indicate that repeated IVTA will prevent the recurrence of uveitis in patients with Behet disease with frequent ocular attacks that is resistant to conventional therapy.