早发性炎症性肠道疾病患儿:对协会登记的IBD患儿的分析
Children with early-onset inflammatory bowel disease (IBD): Analysis of a pediatric IBD consortium registry出 版 物：《世界核心医学期刊文摘（儿科学分册）》 (Dkgest of the World Latest Medical Information)
年 卷 期：2005年第1卷第6期
页 面：32-32页
学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学]
主 题：疾病患儿 IBD 早发性 克罗恩病 结肠疾病 年龄相关性 阳性家族史 人口统计学 显型 家庭成员
摘 要：To determine the characteristics of inflammatory bowel disease (IBD) in young patients. Uniform data were collected from a cohort of patients with IBD who were enrolled from January 2000 to November 2002 at six pediatric centers (Pediatric IBD Consortium). Of 1370 children in the registry, the mean age at IBD diagnosis was 10.3 ±4.4 years; 54%were male, and 86%were white. Diagnosis was confirmed in 87 (6.1%) under 3 years of age, 211 (15.4%) before 6 years, 654 (47.7%) at 6 to 12 years, and 505 (36.9%) at 13 to 17 years. More than 63%of children younger than 8 years of age had isolated colonic disease, whether Crohn disease, ulcerative colitis (UC), or indeterminate colitis. Conversely, only 35%of those 8 years of age or older had isolated colonic disease (P.0001). Overall, 29%had one or more family members with IBD. The subgroup of children younger than 3 years of age with UC had the highest prevalence of first-degree relatives with IBD (44%). This demographically diverse pediatric IBD cohort revealed age-related variation in the distribution of IBD phenotype, with a high prevalence of isolated colonic disease in young children. Positive family history was especially common in young patients with UC.
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