Electrospinning nanofibers to ID,2D,and 3D scaffolds and their biomedical applications

作     者：Huiling Zhong Jun Huang Jun Wu Jianhang Du 

作者机构：Guangdong Innovative Engineering and Technology Research Center for Assisted Circulationthe Eighth Affiliated Hospital of Sun Yat-sen UniversityShenzhen 518033China Key Laboratory of Sensing Technology and Biomedical Instrument of Guangdong ProvinceSchool of Biomedical EngineeringSun Yat-sen UniversityGuangzhou 510006China NHC Key Laboratory of Assisted Circulation(Sun Yat-sen University)Guangzhou 510080China 

出 版 物：《Nano Research》 (纳米研究（英文版）)

年 卷 期：2022年第15卷第2期

页      面：787-804页

核心收录：

学科分类：08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 

基　　金：the funding from Medical Scientific Research Foundation of Guangdong Province(No.A2021093) Science and Technology Planning Project of Shenzhen Municipality(No.YJ20180306174831458) Shenzhen Basic Research Project(No.JCYJ20190807155801657) National Science and Technology Major Project of the Ministry of Science and Technology of China(No.2018ZX10301402) Key International(Regional)Joint Research Program of China(No.5181001045) Guangdong Innovative and Entrepreneurial Research Team Program(No.2016ZT06S029) the National Natural Science Foundation of China(No.51973243) China Postdoctoral Science Foundation(No.2019M663246) the Fundamental Research Funds for the Central Universities(Nos.191gzd35 and 20ykpyl5) Guangdong Basic and Applied Basic Research Foundation(No.2019A1515110686). 

主　　题：electrospinning nanofibers structures three-dimensional(3D)scaffolds tissue engineering 

摘      要：Electrospinning is a popular and effective method of producing porous nanofibers with a large surface area,superior physical and chemical properties,and a controllable pore size.Owing to these properties,electrospun nanofibers can mimic the extracellular matrix and some human tissue structures,based on the fiber configuration.Consequently,the application of electrospun nanofibers as biomaterials,varying from two-dimensional(2D)wound dressings to three-dimensional(3D)tissue engineering scaffolds,has increased rapidly in recent years.Nanofibers can either be uniform fiber strands or coaxial drug carriers,and their overall structure varies from random mesh-like mats to aligned or gradient scaffolds.In addition,the pore size of the fibers can be adjusted or the fibers can be loaded with disparate medicines to provide different functions.This review discusses the various structures and applications of 2D fiber mats and 3D nanofibrous scaffolds made up of different one-dimensional(1D)fibers in tissue engineering.In particular,we focus on the improvements made in recent years,especially in the fields of wound healing,angiogenesis,and tissue regeneration.