Animal models in the study of Alzheimer's disease and Parkinson's disease:A historical perspective

作     者：Rajashree Banerjee Arushi Rai Shreyas M.Iyer Sonia Narwal Meghana Tare Rajashree Banerjee;Arushi Rai;Shreyas M.Iyer;Sonia Narwal;Meghana Tare

作者机构：Department of Biological SciencesBirla Institute of Technology and SciencePilaniIndia 

出 版 物：《Animal Models and Experimental Medicine》 (动物模型与实验医学（英文）)

年 卷 期：2022年第5卷第1期

页      面：27-37页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100203[医学-老年医学] 100204[医学-神经病学] 10[医学] 

基　　金：SMI is funded by Department of Science and Technology Science and Engineering Research Board Early Career grant to MT.SN is supported from Birla Institute of Technology and Science PhD student fellowship at Biological Sciences。 

主　　题：Alzheimer's disease animal models neurodegeneration Parkinson's disease 

摘      要：Alzheimer s disease and Parkinson s disease are two of the most prevalent and disabling neurodegenerative diseases globally.Both are proteinopathic conditions and while occasionally inherited,are largely sporadic in nature.Although the advances in our understanding of the two have been significant,they are far from complete and neither diagnosis nor the current practices in treatment and rehabilitation is adequately helpful.Animal models have historically found application as testing beds for novel therapeutics and continue to be valuable aids in pharmacological research.This review chronicles the development of those models in the context of Alzheimer s and Parkinson s disease,and highlights the shifting paradigms in studying two humanspecific conditions in non-human organisms.