Immunomodulatory hybrid bio-nanovesicle for self-promoted photodynamic therapy
作者机构：School of Life ScienceBeijing Institute of TechnologyBeijing 100081China School of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081China School of StomatologyPerking UniversityBeijing 100081China
出 版 物：《Nano Research》 (纳米研究（英文版）)
年 卷 期：2022年第15卷第5期
页 面：4233-4242页
核心收录：
学科分类：07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0702[理学-物理学]
基 金：This work was funded by the National Natural Science Foundation of China(Nos.21874011,91859123,and 32101140) the National Science Fund for Distinguished Young Scholars(No.22025401) the China Postdoctoral Science Foundation(No.2020M680396) China Postdoctoral Science Foundation(Nos.2021TQ0037 and 2021M690405) The National Natural Science Foundation of China(No.21904012)
主 题：thylakoid photodynamic therapy extracellular vesicle M1 macrophage immunomodulation
摘 要：Thylakoid(Tk)membranes are of unique superiority in photodynamic therapy(PDT)because they not only carry abundant chlorophylls containing photosensitizer porphyrin but also can produce O_(2).However,the current therapeutic performance of Tk is dramatically limited because of their poor tumor targeting and inefficient O_(2) ***,we report an immunomodulatory bio-nanovesicle of Tk membranes fused with M1 macrophage-derived extracellular vesicles(M1 EV)for efficient PDT of *** hybrid nanovesicle Tk@M1 was prepared by squeezing the Tk membranes of spinach with M1 *** systemic study confirmed that Tk@M1 can not only actively accumulate in tumors but also effectively regulate the inactive immune microenvironment of *** activatedhottumors significantly enhance the PDT efficacy of Tk@M1 attributed to the increased O_(2) from catalase catalyzed decomposition of augmented H_(2)O_(2),providing a novel idea about constructing natural systems for effective tumor treatment.
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