Parkin Inhibits Static Mechanical Pain by Suppressing Membrane Trafficking of Mechano-transducing Ion Channel TACAN

作     者：Yi Lei Man-Xiu Xie Xian-Ying Cao Xi Zhang Yi-Bin Xiao Xiao-Yu Tian Yuan-Xin Zhu Xiao-Long Zhang 

作者机构：College of Food Science and EngineeringHainan UniversityHaikou 570228China Medical Research Center of Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Department of AnesthesiologySun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhou 510060China Hainan Senile Health Management Engineering Technology Research CenterHaikou 571126China 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2022年第38卷第4期

页      面：429-434页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071006[理学-神经生物学] 

基　　金：supported by National Natural Science Foundation of China(82001172,82171230) Guangdong Basic and Applied Basic Research Foundation(2019A1515110014) Excellent Young Talents Project of Guangdong Provincial People's Hospital,Guangdong Academy of Medical Sciences Science and Technology Special Foundation of Guangdong Provincial People’s Hospital,Guangdong Academy of Medical Sciences(2020bq20) 

主　　题：stimulation sensation Parkin 

摘      要：Dear Editor,Clinical practice shows that harmless mechanical stimulation can cause pain in humans after inflammation or nerve injury,leading to asensation called mechanical allodynia[].Mechanicalallodyniacomesin many forms:dynamic allodynia caused by something as light as a brushstroke,static allodynia caused by stimulation by weak von Frey filaments[2],which seriously disturbs thequalityof life and working ***,an E3ubiquitin ligase,is linked to neurodegenerative diseases such as Parkinson s disease(PD)and Alzheimer s disease(AD)[3,4].