Experimental animal models of pulmonary hypertension:Development and challenges

作     者：Xiao-Han Wu Jie-Ling Ma Dong Ding Yue-Jiao Ma Yun-Peng Wei Zhi-Cheng Jing Xiao-Han Wu;Jie-Ling Ma;Dong Ding;Yue-Jiao Ma;Yun-Peng Wei;Zhi-Cheng Jing

作者机构：Department of CardiologyState Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Medical Science Research CenterState Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina 

出 版 物：《Animal Models and Experimental Medicine》 (动物模型与实验医学（英文）)

年 卷 期：2022年第5卷第3期

页      面：207-216页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：CAMS Innovation Fund for Medical Sciences (CIFMS):2021-I2M-1-018 

主　　题：animal models BMPR2 chronic hypoxia monocrotaline pulmonary hypertension Sugen 5416 

摘      要：Pulmonary hypertension(PH) is clinically divided into 5 major types, characterized by elevation in pulmonary arterial pressure(PAP) and pulmonary vascular resistance(PVR), finally leading to right heart failure and death. The pathogenesis of this arteriopathy remains unclear, leaving it impossible to target pulmonary vascular remodeling and reverse the deterioration of right ventricular(RV) function. Different animal models have been designed to reflect the complex mechanistic origins and pathology of PH, roughly divided into 4 categories according to the modeling methods: noninvasive models in vivo, invasive models in vivo, gene editing models, and multi-means joint modeling. Though each model shares some molecular and pathological changes with different classes of human PH, in most cases the molecular etiology of human PH is poorly known. The appropriate use of classic and novel PH animal models is essential for the hunt of molecular targets to reverse severe phenotypes.