Targeting DNA repair pathways to overcome cancer drug resistance

作     者：Robert C.A.M.van Waardenburg Eddy S.Yang 

作者机构：Department of Pharmacology and ToxicologyUniversity of Alabama at BirminghamBirminghamAL 35233USA Department of Radiation OncologyUniversity of Alabama at BirminghamBirminghamAL 35233USA O’Neal Comprehensive Cancer CenterUniversity of Alabama at BirminghamBirminghamAL 35233USA 

出 版 物：《Cancer Drug Resistance》 (癌症耐药（英文）)

年 卷 期：2021年第4卷第4期

页      面：837-841页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：van Waardenburg RCAM in part funded by American Cancer Society UAB ACS-IRG Junior Faculty Development Grant(ACS-IRG-60-001-53) Department of Defense OCRP pilot award W81XWH-15-1-0198,and the National Institutes of Health Cancer Center Core Support Grant(P30CA013148) National Institutes of Health-National Institute of Disorders and Stroke(1R21NS116312-01A1). 

主　　题：damage alterations cancer 

摘      要：DNA damage response and DNA repair pathways are evolutionarily conserved from prokaryotes to eukaryotes to protect the host from genomic instability.Dysregulation of proteins involved in these pathways in mammalian cells increases genomic alterations leading to genomic instability,a well-established hallmark of cancer^([1,2]).However,our understanding of the signaling pathways to repair DNA damage in cancers has grown exponentially over the last decades.