Pregnancy outcomes in papillary thyroid cancer survivors:A retrospective cohort study

作     者：Peng Zuo Jingjing Yang Peng Zuo;Jingjing Yang

作者机构：Deparment of Obsteprics and GynecologyPeking University Peqple's HospitalBeyjing China 

出 版 物：《Gynecology and Obstetrics Clinical Medicine》 (妇产科临床医学（英文）)

年 卷 期：2022年第2卷第1期

页      面：20-22页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Research and Development Fund of Peking University People's Hospital(RDY-2020-26) 

主　　题：Papillary thyroid cancer fetal complication maternal complication 

摘      要：Objective:The purpose of this study was to evaluate the pregnancy outcomes among papillary thyroid cancer ***:65 cases singleton gravidas of papillary thyroid cancer survivors treated in the Department of Obstetrics,Peking University People s Hospital between January 2011 and January 2020 were selected retrospectively as the study group,and 130 cases of singleton pregnancy during the same time were randomly selected as the control *** differences in general conditions,maternal and fetal complications between the two groups were *** factors of maternal complications and fetal malformation in patients with papillary thyroid cancer survivors were *** was analyzed with t-test,χ^(2)test and logistic regression for statistical ***:Totally 65 cases of papillary thyroid cancer with 70 pregnancies were analyzed,which including 65 cases achieved live birth,5 cases underwent induced labor because of fetal *** study group showed higher incidence in gestational diabetes(20%vs 10%),cesarean section(39.1%vs 24.6%),postpartum hemorrhage(350
193 ml vs 290
181 ml)and fetal malformation(5.7%vs 1.5%),and lower live birth rate(91.4%vs 99.2%)(P0.05).Multivariate analysis by logistic regression found that the patient s age,thyroid function,operation mode and postoperative I-131 treatment were not the risk factors which may affect the pregnancy outcomes or fetal ***:Elevated maternal and fetal complications were observed among pregnancies in papillary thyroid cancer *** of these survivors may require a careful gestation monitoring,and further investigation is needed.