Modulated illumination localization microscopy-enabled sub-10 nm resolution
作者机构：State Key Laboratory of Modern Optical Instrumentation College of Optical Science and Engineering Zhejiang University Hangzhou 310027P.R.China Collaborative Innovation Center of Extreme Optics Shanxi University Taiyuan 030006P.R.China Research Center for Intelligent Chips and Devices Zhejiang LabHangzhou 311121P.R.China Ningbo Research Institute Zhejiang University Ningbo 315100P.R.China
出 版 物：《Journal of Innovative Optical Health Sciences》 (创新光学健康科学杂志（英文）)
年 卷 期：2022年第15卷第2期
页 面：1-17页
核心收录：
学科分类：070207[理学-光学] 07[理学] 08[工学] 0803[工学-光学工程] 0702[理学-物理学]
基 金：This work was financially sponsored by National Natural Science Foundation of China(61735017,61827825) Major Program of the Natural Science Foundation of Zhejiang Province(LD21F050002) Key Research and Development Program of Zhejiang Province(2020C01116) Fundamental Research Funds for the Central Universities(K20200132),Zhejiang Lab(2020MC0AE01)and Zhejiang Provincial Ten Thousand Plan for Young Top Talents(2020R52001).Y.S.and L.Y.contributed equally to this work
主 题：Fluorescence microscopy modulated illumination single molecule localization microscopy
摘 要：Optical microscopy is an essential tool for exploring the structures and activities of cells and *** break the limit of resolution caused by diffraction,researchers have made continuous advances and innovations to improve the resolution of optical microscopy since the *** contributions,however,still make sub-10nm imaging an ***,we name a series of technologies as modulated illumination localization microscopy(MILM),which makes ultra-high-resolution imaging ***,we review the recent progress since 2017 when MINFLUX was proposed and became the inspiration and foundation for the follow-up devel-opment of *** review divides MILM into two types:point-scanning and *** schematics,principles and future research directions of MILM are discussed elaborately.
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