Vitamin D and Parathyroid Hormone Profiles in Living Kidney Failure Patients in Côte d’Ivoire

作     者：Maxime Roméo Kouadio Lydie Boyvin Gnogbo Alexis Bahi Assieoussou Jean-Luc N’Guessan Cackouoh Carole Constance Koudou Souleymane Méité Allico Joseph Djaman Maxime Roméo Kouadio;Lydie Boyvin;Gnogbo Alexis Bahi;Assieoussou Jean-Luc N’Guessan;Cackouoh Carole Constance Koudou;Souleymane Méité;Allico Joseph Djaman

作者机构：Department of Clinical and Fundamental Biochemistry Institute Pasteur of Cô te d’Ivoire (IPCI) Abidjan Cô te d’Ivoire Health Biology Laboratory University Félix Houphouë t-Boigny (UFHB) Abidjan Cô te d’Ivoire 

出 版 物：《Advances in Biological Chemistry》 (生物化学进展（英文）)

年 卷 期：2022年第12卷第2期

页      面：39-47页

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

主　　题：25-Hydroxyvitamin D Chronic Renal Failure Côte d’Ivoire Secondary Hyperparathyroidism Parathyroid Hormone 

摘      要：Introduction: Abnormalities in mineral and bone metabolism, particularly phosphocalcic metabolism, are common in renal failure and are associated with a significant morbidity and mortality. The regulation of phosphocalcic metabolism is subject to a particularly precise and complex control of parathormone (PTH) and vitamin D. Assessment of vitamin D and parathyroid hormone concentrations would help to improve the medical management of patients with chronic kidney disease and ensure a better quality of life. Methods: The study population consisted of 138 individuals including 46 non- dialysis renal failure patients, 46 chronic hemodialysis patients and 46 non- renal failure volunteers to serve as controls. Serum Parathyroid hormone and Vitamin D concentrations were measured using the Vidas automated system. Results: 25-hydroxyvitamin D concentrations in controls (65 ± 2.41 nmol/L) and dialysis patients (70 ± 3.03 nmol/L) were significantly higher than those in CKD patients (48 ± 3.34 nmol/L). On the other hand, the mean values of Parathyroid hormone in dialysis patients (312 ± 36.22 pg/mL) and CKD patients (117 ± 10.68 pg/mL) were very high compared to that in controls (25 ± 2.34 pg/mL). Conclusion: Secondary hyperparathyroidism is common in renal failure. Parathyroid hormone and 25-hydroxyvitamin D assays would be adequate for better management of chronic renal failure.