Mechanism of hyperproteinemia-induced blood cell homeostasis imbalance in an animal model

作     者：Guang Wang Yong-Feng Wang Jiang-Lan Li Ru-Ji Peng Xin-Yin Liang Xue-Dong Chen Gui-Hua Jiang Jin-Fang Shi Yang-Hu Si-Ma Shi-Qing Xu Guang Wang;Yong-Feng Wang;Jiang-Lan Li;Ru-Ji Peng;Xin-Yin Liang;Xue-Dong Chen;Gui-Hua Jiang;Jin-Fang Shi;Yang-Hu Si-Ma;Shi-Qing Xu

作者机构：School of Biology and Basic Medical SciencesSuzhou Medical CollegeSoochow UniversitySuzhouJiangsu 215123China Department of Clinical LaboratoryFirst Affiliated Hospital of Soochow UniversitySuzhouJiangsu 215006China 

出 版 物：《Zoological Research》 (动物学研究（英文）)

年 卷 期：2022年第43卷第3期

页      面：301-318页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(31972625) China Postdoctoral Science Foundation(2020M681718) Priority Academic Program Development(PAPD)of Jiangsu Higher Education Institutions Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX21_2963) China Agriculture Research System(CARS)of Ministry of Finance and Ministry of Agriculture and Rural Areas 

主　　题：Animal model Blood cell homeostasis High plasma protein concentration(HPPC) JAK/STAT pathway Programmed cell death 

摘      要：Hyperproteinemia is a metabolic disorder associated with increased plasma protein concentration(PPC)and is often clinically complicated by malignant diseases or severe *** present,however,research on the molecular mechanism underlying high PPC(HPPC)is ***,an animal model of primary hyperproteinemia was constructed in an invertebrate(Bombyx mori)to investigate the effects of HPPC on circulating blood *** showed that HPPC affected blood cell homeostasis,leading to increased reactive oxygen species levels,and induced programmed cell death dependent on the endoplasmic reticulum-calcium ion signaling *** induced the proliferation of blood cells,mainly granulocytes,by activating the Janus kinase/signal transducer and activator of transcription(JAK/STAT)signaling *** with the endocrine hormone active substance 20 E significantly reduced the impact of HPPC on blood cell ***,we identified a novel signaling pathway by which HPPC affects blood cell homeostasis,which differs from hyperglycemia,hyperlipidemia,and *** addition,we showed that down-regulation of gene expression of the hematopoietic factor Gcm could be used as a potential early detection indicator for hyperproteinemia.