Gender as an effect modifler in the relationship between hypertension and reticular pseudodrusen in patients with early or intermediate age-related macular degeneration

作     者：Nathaniel Gelinas Anne M.Lynch Marc T.Mathias Alan G.Palestine Naresh Mandava Karen L Christopher Jennifer L.Patnaik University of Colorado Retina Research Group 

作者机构：Department of OphthalmologyUniversity of Colorado School of MedicineAuroraCO 80045USA 

出 版 物：《International Journal of Ophthalmology(English edition)》 (国际眼科杂志（英文版）)

年 卷 期：2022年第15卷第3期

页      面：461-465页

核心收录：

学科分类：1002[医学-临床医学] 100212[医学-眼科学] 10[医学] 

基　　金：Supported by the National Eye Institute of the National Institutes of Health [No.R01EY032456 (AML)] Research to Prevent Blindness grant to the Department of Ophthalmology,University of Colorado,the Frederic C. Hamilton Macular Degeneration Center the Sue Anschutz-Rogers Eye Center Research Fund by NIH/NCATS Colorado CTSA (No.UL1 TR002535) 

主　　题：reticular pseudodrusen hypertension gender intermediate age-related macular degeneration 

摘      要：AIM: To determine whether the prevalence of treated hypertension is higher among males or females with early/intermediate(e/i) age-related macular degeneration(AMD) with and without bilateral reticular pseudodrusen(RPD).METHODS: Retrospective review of the records of patients with e/iAMD who were recruited into the University of Colorado AMD registry between July 2014 and November *** were classified using the Beckman Initiative criteria and presence/absence of *** were categorized into three groups: 1) e/iAMD with RPD;2) e/iAMD without RPD;3) control patients who did not have *** logistic regression analysis was used for adjusted analysis with odds ratios(OR) and confidence intervals(CI).RESULTS: There were 260 patients with e/iAMD of which 101 had bilateral RPD and 159 had no RPD, and 221 ***, 62% of patients were female and the three groups did not differ by *** stratified by gender, the female e/iAMD/RPD group had a higher prevalence of hypertension, 64.1% vs 45.2% for controls, OR=2.2(95%CI: 1.2-4.0).The frequency of hypertension in the e/iAMD/no RPD group was 54.1% and did not significantly differ from the control *** males, prevalence rates of treated hypertension did not *** is a significant interaction of hypertension and gender for the e/iAMD/RPD group such that women with e/iAMD who had RPD were significantly more likely to have hypertension(P=0.042).This relationship was not significant in the e/iAMD/no RPD group(P=0.269).CONCLUSION: Among females treated hypertension is significantly higher among e/iAMD/RPD patients, whereas for males there is no significant association.