Regulation of drug release performance using mixed doxorubicin-doxorubicin dimer nanoparticles as a pH-triggered drug self-delivery system

作     者：Jiagen Li Xinming Li Pengwei Xie Peng Liu Jiagen Li;Xinming Li;Pengwei Xie;Peng Liu

作者机构：State Key Laboratory of Applied Organic ChemistryCollege of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou730000China 

出 版 物：《Journal of Pharmaceutical Analysis》 (药物分析学报（英文版）)

年 卷 期：2022年第12卷第1期

页      面：122-128页

核心收录：

学科分类：100702[医学-药剂学] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

主　　题：Drug self-delivery system Regulated drug release Doxorubicin-doxorubicin dimer Acid-triggered release Mixed nanoparticles 

摘      要：A mixed drug self-delivery system(DSDS)with high drug content(50%)was developed to regulate pHtriggered drug release,based on two doxorubicin(DOX)-DOX dimmers:D-DOX_(ADH) and D-DOX_(car) conjugated with acid-labile dynamic covalent bonds(hydrazone and carbamate,respectively)and stabilized with PEGylated D-DOX_(ADH)(D-DOX_(ADH)-PEG).Owing to the different stability of the dynamic covalent bonds in the two dimers and the noncovalent interaction between them,pH-triggered drug release could be easily regulated by adjusting the feeding ratios of the two DOX-DOX dimers in the mixed *** in vitro cellular toxicity was achieved with the mixed DSDS nanoparticles prepared with different feeding *** mixed DSDS nanoparticles had a similar DOX content and diameter but different drug releasing *** MTT assays revealed that a high anti-tumor efficacy could be achieved with the slowrelease mixed DSDS nanoparticles.