Molecular targets of cancer chemoprevention by garlic-derived organosulfides

作     者：Anna HERMAN-ANTOSIEWICZ Anna A POWOLNY Shivendra V SINGH 

作者机构：Department of Molecular Biology University of Gda(skKladki 2480-822 GdaskPoland Department of Pharmacology and University of Pittsburgh Cancer InstituteUniversity of Pittsburgh School of MedicinePittsburghPennsylvania 15213USA 

出 版 物：《Acta Pharmacologica Sinica》 (中国药理学报(英文版))

年 卷 期：2007年第28卷第9期

页      面：1355-1364页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Studies from our laboratory cited in this review were supported by United States Public Health Service grants CA55589 and CA113363 awarded by the National Cancer Institute 

主　　题：garlic organosulfides apoptosis cell cycle angiogenesis chemoprevention 

摘      要：The medicinal benefits of Allium vegetables,especially garlic,have been notedthroughout recorded *** known health benefits of Allium vegetablesand their constituents include cardiovascular protective effects,stimulation ofimmune function,reduction of blood glucose level,radioprotection,improvementof memory loss,protection against microbial,viral and fungal infections,as well asanticancer ***-based case control studies have suggested aninverse correlation between dietary intake of Allium vegetables and the risk ofdifferent types of *** anticarcinogenic effect of Allium vegetables in-cluding garlic is attributed to organosulfur compounds (OSC),which are highlyeffective in affording protection against cancer in animal models induced by avariety of chemical *** recent studies have shown that certainnaturally occurring OSC analogues can suppress proliferation of cancer cells inculture and in *** OSC-induced changes in the proliferation of cancer cellsare frequently associated with perturbations in cell cycle progression and induc-tion of G2/M phase *** OSC have also been demonstrated to induceapoptosis via the intrinsic pathway by altering the ratio of the Bcl-2 family ofproteins both in cell culture and in in vivo ***-angiogenic activity forgarlic-derived OSC has also been *** article summarizes currentknowledge on molecular targets of cancer chemoprevention by OSC.