Altered influenza virus haemagglutinin(HA)-derived peptide is potent therapy for CIA by inducing Th1 to Th2 shift
作者机构：Department of Rheumatology and ImmunologyClinical Immunology CenterPeking University People’s HospitalBeijingChina
出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)
年 卷 期：2011年第8卷第4期
页 面：348-358页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：grants from the National Major Scientific and Technological Specialized Project(2009ZX09103-746) National Program on Key Basic Research Project(2010CB529100) National Natural Science Foundation of China(30700751)
主 题：altered HA peptide collagen-induced arthritis Th1/Th2
摘 要：There has been an increase in interest in the use of altered peptides as antigen-specific therapeutic agents in autoimmune *** we investigated the inhibitory effect and possible mechanism of an altered influenza virus haemagglutinin(HA)-derived peptide in collagen-induced arthritis(CIA).CIA was induced in DBA/1 mice by immunisation with type II collagen(CII).Altered HA308-317,wild-type HA308-317 or irrelevant peptide was administered intranasally beginning from arthritis *** and histological scores were assessed,and cytokine levels in the serum or supernatants from splenocytes were *** percentages of Th1 and Th2 cells in response to different peptides were analysed by FACS both in vivo and in *** results showed that intranasal administration of altered HA308-317 peptide significantly ameliorated *** therapeutic effect of altered HA308-317 peptide was associated with a substantial decrease in production of interferon(IFN)-c,interleukin(IL)-6,monocyte chemoattractant protein(MCP)-1,anti-CII IgG,IgG1 and IgG2a antibodies,and an markedly increase in production of IL-10 and IL-4 in serum or supernatants from splenocytes treated with altered HA308-317 *** percentage of Th2(CD41IL-41)cells was upregulated significantly by altered HA308-317 peptide with a decreased percentage of Th1(T helper 1;CD41INF-c1)cells both in vivo and in *** findings suggest that altered HA308-317 peptide might be a promising candidate for rheumatoid arthritis(RA)treatment.
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