LncRNA MEG3 promotes chemosensitivity of osteosarcoma by regulating antitumor immunity via miR-21-5p/p53 pathway and autophagy

作     者：Xin Huang Weiyue Zhang Feifei Pu Zhicai Zhang Xin Huang;Weiyue Zhang;Feifei Pu;Zhicai Zhang

作者机构：Department of OrthopaedicsUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of EndocrinologyUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China 

出 版 物：《Genes & Diseases》 (基因与疾病（英文）)

年 卷 期：2023年第10卷第2期

页      面：531-541页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by The National Natural Science Foundation of China(No.82072979) 

主　　题：Antitumor immunity Autophagy Chemosensitivity LncRNAMEG3 Osteosarcoma 

摘      要：This study aimed to investigate the role of long non-coding RNA maternally expressed gene 3(lncRNA MEG3)in chemosensitivity of osteosarcoma(OS),and to reveal the possible underlying *** this study,we found that the expression of lncRNA MEG3 was significantly lower in OS tissues and cell ***,lncRNA MEG3 overexpression enhanced chemosensitivity of OS by inhibiting cell proliferation,migration,autophagy,and promoting antitumor *** MEG3 functioned as miR-21-5 sponge to regulate p53 expression in ***,lncRNA MEG3 promoted OS chemosensitivity by regulating antitumor immunity via miR-21-5p/p53 pathway and ***,this study provided the evidence that lncRNA MEG3 might be a promising therapeutic target for OS chemoresistance.