Stereoselective formation of Z-monofluoroalkenes by nickel-catalyzed defluorinative coupling of gem‑difluoroalkenes with lithium organoborates

作     者：Yisa Xiao Weichen Huang Qilong Shen Yisa Xiao;Weichen Huang;Qilong Shen

作者机构：Key Laboratory of Organofluorine ChemistryShanghai Institute of Organic ChemistryUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200032China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2022年第33卷第9期

页      面：4277-4280页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：the National Natural Science Foundation of China(Nos.21625206.21632009 21421002 22061160465)for financial support 

主　　题：gem‑Difluoroalkenes Lithium organoborate Defluorination Nickel Coupling 

摘      要：A method for stereoselective construction of Z-monofluoroalkenes by nickel-catalyzed defluorinative coupling of gem‑difluoroalkenes in mild conditions was *** combination of lithium organoborate and ZnBr_(2) generated in situ lithium aryl zincates,which facilitates the transmetalation step of the nickel-catalyzed cross coupling reaction.