Stem cell-laden hydrogel bioink for generation of high resolution and fidelity engineered tissues with complex geometries
作者机构：Department of Biomedical EngineeringUniversity of Illinois at ChicagoChicagoIL60607USA Department of ChemistryUniversity of Illinois at ChicagoChicagoIL60607USA Department of OrthopaedicsUniversity of Illinois at ChicagoChicagoIL60607USA Department of PharmacologyUniversity of Illinois at ChicagoChicagoIL60607USA Department of Mechanical and Industrial EngineeringUniversity of Illinois at ChicagoChicagoIL60607USA
出 版 物：《Bioactive Materials》 (生物活性材料（英文）)
年 卷 期：2022年第7卷第9期
页 面：185-193页
核心收录：
学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0836[工学-生物工程]
主 题：3D bioprinting Hydrogel bioink Biomaterial High resolution and fidelity
摘 要：Recently,3D bioprinting has been explored as a promising technology for biomedical applications with the potential to create complex structures with precise *** encapsulated hydrogels composed of materials such as gelatin,collagen,hyaluronic acid,alginate and polyethylene glycol have been widely used as bioinks for 3D ***,since most hydrogel-based bioinks may not allow rapid stabilization immediately after 3D bioprinting,achieving high resolution and fidelity to the intended architecture is a common challenge in 3D bioprinting of *** this study,we have utilized shear-thinning and self-healing ionically crosslinked oxidized and methacrylated alginates(OMAs)as a bioink,which can be rapidly gelled by its self-healing property after bioprinting and further stabilized via secondary *** was successfully demonstrated that stem cell-laden calcium-crosslinked OMA hydrogels can be bioprinted into complicated 3D tissue structures with both high resolution and *** photocrosslinking enables long-term culture of 3D bioprinted constructs for formation of functional tissue by differentiation of encapsulated human mesenchymal stem cells.
维普期刊数据库