Reversing neuromuscular blocking agent decamethonium by carboxylatopillar[6]arene based on host-guest encapsulation

作     者：Yao Chai Longming Chen Yahan Zhang Liang Zhao Zhao Meng Junyi Chen Chunju Li Qingbin Meng Yao Chai;Longming Chen;Yahan Zhang;Liang Zhao;Zhao Meng;Junyi Chen;Chunju Li;Qingbin Meng

作者机构：State Key Laboratory of Toxicology and Medical CountermeasuresBeijing Institute of Pharmacology and ToxicologyBeijing 100850China Key Laboratory of Inorganic-Organic Hybrid Functional Material ChemistryMinistry of EducationTianjin Key Laboratory of Structure and Performance for Functional MoleculesCollege of ChemistryTianjin Normal UniversityTianjin 300387China Key Laboratory of Natural Resources and Functional Molecules of the Changbai MountainAffiliated Ministry of EducationCollege of PharmacyYanbian UniversityYanji 133002China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2022年第33卷第6期

页      面：3003-3006页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 0703[理学-化学] 10[医学] 

基　　金：the Natural Science Foundation of Beijing Municipality(No.7204285) the National Natural Science Foundation of China(Nos.81573354,21772118,21971192) 

主　　题：Host-guest encapsulation Decamethonium Neuromuscular blocking agents Supramolecular strategy Carboxylatopillararene 

摘      要：Neuromuscular blocking agents(NMBAs)are extensively used during anesthesia to improve surgical conditions by relaxing skeletal muscle *** neuromuscular recovery after surgery is desirable to facilitate the recovery of muscle function and prevent residual ***(C10)is a classic NMBA,which has been restricted over the past decades ascribed to lack of a suitable antidote in *** we used carboxylatopillar[6]arene(CP6A)to reverse neuromuscular blocker effect of C10 through direct host-guest *** and isothermal titration calorimetry served to confirm the complexation between CP6A and C10 with robust affinity[(1.07±0.14)×10^(7)L/mol].The CP6A was further used as a reversal agent of C10,which facilitated to decrease C10 concentration in mice blood and excrete via urinary clearance,resulting in rapid recovery from muscle *** favorable outcomes might lead us to suggest that this supramolecular strategy could allow patients to regain lucidity much faster than spontaneous recovery from anesthesia.