Distinctive Cassane Diterpenoids Corroborated Biogenetic Evolutionary Process from Caesalpinia mimosoides with Anti-renal Fibrosis Activity
作者机构：School of Traditional Chinese Materia MedicaShenyang Pharmaceutical UniversityShenyangLiaoning110016 China Key Laboratory of Structure-Based Drug Design&Discovery of Ministry of EducationShenyang Pharmaceutical UniversityShenyangLiaoning110016 China
出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)
年 卷 期：2022年第40卷第5期
页 面：617-627页
核心收录：
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
基 金：The authors are grateful to the received financial support from the National Natural Science Foundation of China(No.31670359) the Liaoning Revitallzation Talents Program(No.XLYC 1905019) the Natural Science Foundation of Llaoning Province(No.201602691)
主 题：Cassane diterpene Caesalpinia mimosoides Natural products Molecular evolution Biological activity
摘 要：Eighteen diterpenoids were isolated from the seeds of Caesalpinia mimosoides,including four extremely infrequent cassane diterpenes,together with nine new and five known *** 7 and 8 represent the first examples of cassane diterpenoids fused with a ketone carbonyl and a ternary oxygen ring at C-4,*** 9 and 10 possess a rare five-member ring in cassane ***,these isolated components are a clue to the fact that there are lower and higher levels in the plant secondary metabolites,demonstrating the evolution of secondary metabolism of *** the isolated compounds were tested for their anti-renal fibrosis activity against TGF-β1 induced NRK-52E cell *** mRNA levels of fibrosis markerα-SMA,E-cadherin,Collagen I were tested by *** data showed compounds 6 and 9 exhibited the best anti-renal fibrosis activity and provided preliminary structure−activity relationships.
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